Overview

Urethral carcinomas most frequently harbor alterations in TP53, PIK3CA, KDM6A, FGFR3, and ARID1A [2].

Most Commonly Altered Genes in Urethral Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KDM6A Mutation, and FGFR3 Mutation are the most common alterations in urethral carcinoma [2].

Top Alterations in Urethral Carcinoma

Significant Genes in Urethral Carcinoma

ERBB2 +

TP53 +

Disease Details

Parent(s)
Malignant Urethral Neoplasm
Children
Urethral Squamous Cell Carcinoma, Accessory Urethral Gland Carcinoma, Urethral Urothelial Carcinoma, and Urethral Adenocarcinoma
OncoTree Name
Urethral Cancer
OncoTree Code
UCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.