Urethral carcinomas most frequently harbor alterations in TP53, FGFR3, PIK3CA, KDM6A, and CDKN2A [2].

Most Commonly Altered Genes in Urethral Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, FGFR3 Mutation, and PIK3CA Mutation are the most common alterations in urethral carcinoma [2].

Top Alterations in Urethral Carcinoma

Disease Details

Malignant Urethral Neoplasm
Urethral Squamous Cell Carcinoma, Urethral Urothelial Carcinoma, Accessory Urethral Gland Carcinoma, and Urethral Adenocarcinoma
OncoTree Name
Urethral Cancer
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.