Diseases /
Urethral Squamous Cell Carcinoma
Overview
NCI Definition: A well differentiated, moderately differentiated, or poorly differentiated squamous cell carcinoma that arises from the male or female urethra. [1]
Urethral squamous cell carcinomas most frequently harbor alterations in PIK3CA, TP53, PIK3C2G, YES1, and SOCS1 [2].
PIK3CA Mutation, PIK3CA E542K, PIK3CA Codon 542 Missense, TP53 c.217-c.1178 Missense, and TP53 Mutation are the most common alterations in urethral squamous cell carcinoma [2].
Clinical Trials
Significant Genes in Urethral Squamous Cell Carcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.