NCI Definition: A well differentiated, moderately differentiated, or poorly differentiated squamous cell carcinoma that arises from the male or female urethra. [1]

Urethral squamous cell carcinomas most frequently harbor alterations in PIK3CA, TP53, PIK3C2G, YES1, and SOCS1 [2].

Most Commonly Altered Genes in Urethral Squamous Cell Carcinoma

PIK3CA Mutation, PIK3CA E542K, PIK3CA Codon 542 Missense, TP53 c.217-c.1178 Missense, and TP53 Mutation are the most common alterations in urethral squamous cell carcinoma [2].

Top Alterations in Urethral Squamous Cell Carcinoma

Significant Genes in Urethral Squamous Cell Carcinoma

CD274 +

Disease Details

Squamous Cell Carcinoma of the Urethra, Urethra Squamous Cell Carcinoma, Urethral Epidermoid Carcinoma, Epidermoid Carcinoma of the Urethra, Urethra Epidermoid Carcinoma, Squamous Cell Carcinoma of Urethra, Epidermoid Carcinoma of Urethra
Urethral Carcinoma
Urethral Verrucous Carcinoma
OncoTree Name
Urethral Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.