Overview

NCI Definition: A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma. [1]

Uterine carcinosarcomas most frequently harbor alterations in TP53, PIK3CA, KRAS, FBXW7, and CCNE1 [2].

Most Commonly Altered Genes in Uterine Carcinosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and FBXW7 Mutation are the most common alterations in uterine carcinosarcoma [2].

Top Alterations in Uterine Carcinosarcoma

Significant Genes in Uterine Carcinosarcoma

EGFR +

ERBB2 +

TP53 +

Disease Details

Synonyms
Carcinosarcoma of the Uterus, Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus, Uterine Malignant Mixed Mesodermal (Mullerian) Tumor
Parent(s)
Malignant Uterine Neoplasm
Children
Uterine Corpus Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.