Overview

NCI Definition: An aggressive malignant mixed epithelial and mesenchymal tumor that arises from the uterine corpus. It usually affects elderly postmenopausal women and presents with vaginal bleeding. It is characterized by the presence of a malignant epithelial component that is usually glandular and a sarcomatous component. [1]

Uterine corpus carcinosarcomas most frequently harbor alterations in TP53, PIK3CA, KRAS, FBXW7, and CCNE1 [2].

Most Commonly Altered Genes in Uterine Corpus Carcinosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in uterine corpus carcinosarcoma [2].

Top Alterations in Uterine Corpus Carcinosarcoma

Significant Genes in Uterine Corpus Carcinosarcoma

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

POLE +

Disease Details

Synonyms
Carcinosarcoma of Uterus, Carcinosarcoma of the Corpus Uteri, Uterine Corpus Malignant Mixed Mullerian Tumor, Mixed Müllerian Sarcoma of Uterus, Malignant Mixed Mesodermal Tumor of the Uterine Body, Uterine Corpus Malignant Mixed Mullerian Neoplasm, Carcinosarcoma of the Uterus, Uterine Body Malignant Mixed Mesodermal Neoplasm, Uterine Corpus Malignant Mixed Müllerian Tumor, Uterine Mixed Mullerian Sarcoma, Uterine Malignant Mixed Mesodermal Neoplasm, Malignant Mixed Mesodermal Neoplasm of the Uterus, Uterine Corpus Malignant Mixed Mesodermal (Müllerian) Tumor, Uterine Body Carcinosarcoma, Malignant Mixed Mesodermal Tumor of Uterine Corpus, Uterine Corpus Malignant Mixed Mesodermal Tumor, Malignant Mixed Mesodermal Neoplasm of Uterine Corpus, Uterine Mixed Müllerian Sarcoma, Uterine Corpus Malignant Mixed Müllerian Neoplasm, Uterine Malignant Mixed Mesodermal Tumor, Corpus Uteri Malignant Mixed Mesodermal Tumor, Malignant Mixed Mesodermal Neoplasm of Uterine Body, Carcinosarcoma of Corpus Uteri, Uterine Body Malignant Mixed Mesodermal Tumor, Uterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor, Mixed Müllerian Sarcoma of the Uterus, Carcinosarcoma of the Uterine Body, Mixed Mullerian Sarcoma of Uterus, Malignant Mixed Mesodermal Tumor of Uterine Body, Malignant Mixed Mesodermal Tumor of the Uterus, Carcinosarcoma of Uterine Body, Uterine Corpus Malignant Mixed Mesodermal Neoplasm, Carcinosarcoma of Uterine Corpus, Malignant Mixed Mesodermal Neoplasm of Uterus, Malignant Mixed Mesodermal Tumor of the Uterine Corpus, Carcinosarcoma of the Uterine Corpus, Malignant Mixed Mesodermal Neoplasm of the Uterine Body, Malignant Mixed Mesodermal Tumor of Uterus, Mixed Mullerian Sarcoma of the Uterus, Malignant Mixed Mesodermal Neoplasm of the Uterine Corpus, Uterine Carcinosarcoma
Parent(s)
Uterine Corpus Cancer
OncoTree Name
Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor
OncoTree Code
UCS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.