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Uterine Corpus Leiomyoma

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Overview

NCI Definition: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [1]

Uterine corpus leiomyomas most frequently harbor alterations in USP28, TSC2, TSC1, TP53, and RUNX1 [2].

Most Commonly Altered Genes in Uterine Corpus Leiomyoma

USP28 R732H, TSC2 R691L, TSC2 Mutation, TSC1 Mutation, and TSC1 M351V are the most common alterations in uterine corpus leiomyoma [2].

Top Alterations in Uterine Corpus Leiomyoma

Clinical Trials

View Clinical Trials for Uterine Corpus Leiomyoma

Disease Details

Synonyms
Fibroid of the Uterine Corpus, Leiomyoma of Corpus Uteri, Leiomyoma of the Body of Uterus, Leiomyoma of Uterine Body, Fibroid of Uterine Corpus, Leiomyoma of the Corpus Uteri, Uterine Fibroid, Uterine Body Fibroid, Fibroid of Corpus Uteri, Corpus Uteri Fibroid, Uterine Body Leiomyoma, Leiomyoma of the Uterine Corpus, Fibroid of the Corpus Uteri, Body of Uterus Leiomyoma, Leiomyoma of Uterine Corpus, Body of Uterus Fibroid, Uterine Corpus Fibroid, Fibroid of Uterine Body, Fibroid of the Uterine Body, Corpus Uteri Leiomyoma, Leiomyoma of the Uterine Body, Fibroid of the Body of Uterus, Uterine Corpus Leiomyomata, Leiomyoma of Body of Uterus, Fibroid of Body of Uterus
Parent(s)
Uterine Corpus Smooth Muscle Neoplasm
Children
Uterine Corpus Cellular Leiomyoma, Uterine Corpus Dissecting Leiomyoma, Uterine Corpus Lipoleiomyoma, Uterine Corpus Epithelioid Leiomyoma, Uterine Corpus Myxoid Leiomyoma, and Uterine Corpus Bizarre Leiomyoma
OncoTree Name
Uterine Leiomyoma
OncoTree Code
ULM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.