Overview

NCI Definition: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [1]

Uterine corpus leiomyomas most frequently harbor alterations in USP28, TSC2, TSC1, TP53, and RUNX1 [2].

Most Commonly Altered Genes in Uterine Corpus Leiomyoma

USP28 R732H, TSC2 R691L, TSC2 Mutation, TSC1 Mutation, and TSC1 M351V are the most common alterations in uterine corpus leiomyoma [2].

Top Alterations in Uterine Corpus Leiomyoma

Disease Details

Synonyms
Leiomyoma of the Uterine Body, Leiomyoma of Corpus Uteri, Body of Uterus Leiomyoma, Leiomyoma of Uterine Body, Uterine Fibroid, Fibroid of the Uterine Body, Leiomyoma of the Corpus Uteri, Uterine Body Leiomyoma, Fibroid of Uterine Body, Corpus Uteri Leiomyoma, Corpus Uteri Fibroid, Uterine Body Fibroid, Leiomyoma of Body of Uterus, Leiomyoma of Uterine Corpus, Body of Uterus Fibroid, Fibroid of Uterine Corpus, Fibroid of the Uterine Corpus, Fibroid of the Body of Uterus, Fibroid of Corpus Uteri, Leiomyoma of the Body of Uterus, Uterine Corpus Fibroid, Fibroid of Body of Uterus, Leiomyoma of the Uterine Corpus, Fibroid of the Corpus Uteri, Uterine Corpus Leiomyomata
Parent(s)
Uterine Benign Neoplasm
Children
Uterine Corpus Myxoid Leiomyoma, Uterine Corpus Epithelioid Leiomyoma, Uterine Corpus Bizarre Leiomyoma, Uterine Corpus Dissecting Leiomyoma, Uterine Corpus Cellular Leiomyoma, and Uterine Corpus Lipoleiomyoma
OncoTree Name
Uterine Leiomyoma
OncoTree Code
ULM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.