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Uterine Corpus Leiomyosarcoma

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Overview

NCI Definition: An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells. [1]

Uterine corpus leiomyosarcomas most frequently harbor alterations in TP53, RB1, ATRX, MED12, and PTEN [2].

Most Commonly Altered Genes in Uterine Corpus Leiomyosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and ATRX Mutation are the most common alterations in uterine corpus leiomyosarcoma [2].

Top Alterations in Uterine Corpus Leiomyosarcoma

Clinical Trials

View Clinical Trials for Uterine Corpus Leiomyosarcoma

Disease Details

Synonyms
Leiomyosarcoma of the Corpus Uteri, Leiomyosarcoma of Corpus Uteri, Leiomyosarcoma of Body of Uterus, Corpus Uteri Leiomyosarcoma, Leiomyosarcoma of Uterine Body, Leiomyosarcoma of the Uterus, Leiomyosarcoma - uterus, Leiomyosarcoma of Uterine Corpus, Leiomyosarcoma of Uterus, Leiomyosarcoma of the Body of Uterus, Uterus leiomyosarcoma, Leiomyosarcoma of the Uterine Corpus, Leiomyosarcoma of the Uterine Body, Uterine Body Leiomyosarcoma, Body of Uterus Leiomyosarcoma
Parent(s)
Uterine Corpus Smooth Muscle Neoplasm
Children
Uterine Corpus Myxoid Leiomyosarcoma and Uterine Corpus Epithelioid Leiomyosarcoma
OncoTree Name
Uterine Leiomyosarcoma
OncoTree Code
ULMS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.