Overview

NCI Definition: An epithelial neoplasm with neuroendocrine differentiation that arises from the uterine corpus. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma. [1]

Uterine corpus neuroendocrine neoplasms most frequently harbor alterations in TP53 [2].

Most Commonly Altered Genes in Uterine Corpus Neuroendocrine Neoplasm

TP53 c.217-c.1178 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in uterine corpus neuroendocrine neoplasm [2].

Top Alterations in Uterine Corpus Neuroendocrine Neoplasm

Disease Details

Synonyms
Uterine Corpus Neuroendocrine Tumor
Parent(s)
Neuroendocrine Carcinoma
Children
Endometrial Small Cell Carcinoma
OncoTree Name
Uterine Neuroendocrine Carcinoma
OncoTree Code
UNEC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.