Associated Genetic Biomarkers
Uterine sarcomas most frequently harbor alterations in TP53, RB1, ATRX, PTEN, and CDKN2A .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and ATRX Mutation are the most common alterations in uterine sarcoma .
There is 1 clinical trial for uterine sarcoma, of which 1 is open and 0 are completed or closed. Of the trial that contains uterine sarcoma as an inclusion criterion, 1 is phase 1 (1 open).
Z-endoxifen is the most common intervention in uterine sarcoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.