Vulvar Squamous Intraepithelial Lesion
Associated Genetic Biomarkers
NCI Definition: An intraepithelial lesion of the vulvar squamous epithelium commonly associated with HPV infection. It includes low and high grade squamous intraepithelial lesions. Low grade squamous intraepithelial lesion is considered a non-neoplastic lesion. High grade squamous intraepithelial lesion is neoplastic. 
There is 1 clinical trial for vulvar squamous intraepithelial lesion, of which 0 are open and 1 is completed or closed. Of the trial that contains vulvar squamous intraepithelial lesion as an inclusion criterion, 1 is phase 2 (0 open).
CDKN2A, HLA-A*02:01, and HPV are the most frequent gene inclusion criteria for vulvar squamous intraepithelial lesion clinical trials .
Hpv-16 e7 tcr expressing t-cells is the most common intervention in vulvar squamous intraepithelial lesion clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.