NCI Definition: A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation. [1]

Well differentiated liposarcomas most frequently harbor alterations in MDM2, CDK4, GLI1, SDHC, and DDR2 [2].

Most Commonly Altered Genes in Well Differentiated Liposarcoma

MDM2 Amplification, CDK4 Amplification, GLI1 Amplification, SDHC Amplification, and DDR2 Amplification are the most common alterations in well differentiated liposarcoma [2].

Top Alterations in Well Differentiated Liposarcoma

Disease Details

Well Differentiated Liposarcoma of Deep Soft Tissue, Well-Differentiated Liposarcoma
Spindle Cell Liposarcoma, Sclerosing Liposarcoma, and Inflammatory Liposarcoma
OncoTree Name
Well-Differentiated Liposarcoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.