Overview

NCI Definition: An adenocarcinoma arising from the thyroid gland showing extensive evidence of follicular cell differentiation. According to the nuclear features of the malignant follicular cells, it is classified either as papillary, or follicular carcinoma. [1]

Well-differentiated thyroid gland carcinomas most frequently harbor alterations in BRAF, NRAS, HRAS, TP53, and ATM [2].

Most Commonly Altered Genes in Well-Differentiated Thyroid Gland Carcinoma

BRAF Mutation, BRAF Exon 15 Mutation, BRAF V600E, BRAF Codon 600 Missense, and NRAS Mutation are the most common alterations in well-differentiated thyroid gland carcinoma [2].

Top Alterations in Well-Differentiated Thyroid Gland Carcinoma

Significant Genes in Well-Differentiated Thyroid Gland Carcinoma

ERBB2 +

Disease Details

Synonyms
Thyroid Gland Differentiated Carcinoma, Differentiated Thyroid Cancer, Well Differentiated Thyroid Carcinoma, Well-Differentiated Thyroid Cancer, Thyroid Gland Well Differentiated Carcinoma, Differentiated Thyroid Gland Cancer, Well Differentiated Thyroid Gland Carcinoma, Differentiated Thyroid Carcinoma, Differentiated Thyroid Gland Carcinoma
Parent(s)
Thyroid Gland Adenocarcinoma
Children
Thyroid Gland Papillary Carcinoma and Thyroid Gland Follicular Carcinoma
OncoTree Name
Well-Differentiated Thyroid Cancer
OncoTree Code
WDTC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.