Overview

NCI Definition: A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma. [1]

WHO grade III gliomas most frequently harbor alterations in IDH1, TP53, ATRX, CIC, and CDKN2A [2].

Most Commonly Altered Genes in WHO Grade III Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 Missense are the most common alterations in WHO grade III glioma [2].

Top Alterations in WHO Grade III Glioma

Significant Genes in WHO Grade III Glioma

ATRX +

EGFR +

ERBB2 +

IDH1 +

IDH2 +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

TP53 +

Disease Details

Synonyms
Anaplastic Glioma
Parent(s)
Malignant Glioma
Children
Anaplastic Ependymoma, Anaplastic Oligoastrocytoma, Anaplastic Astrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, and Anaplastic Oligodendroglioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.