Associated Genetic Biomarkers
NCI Definition: An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix. 
Wilms tumors most frequently harbor alterations in TP53, MYCN, APC, WT1, and FGFR1 .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in Wilms tumor .
There are 3 clinical trials for Wilms tumor, of which 2 are open and 1 is completed or closed. Of the trials that contain Wilms tumor as an inclusion criterion, 1 is phase 1 (0 open) and 2 are phase 2 (2 open).
Celecoxib, cyclophosphamide, and etoposide are the most common interventions in Wilms tumor clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.