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melatonin

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Overview

NCI Definition [1]:
A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters.

Clinical Trials

View Clinical Trials for melatonin

Melatonin has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating melatonin, 1 is phase 2 (1 open).

ER Positive is the most frequent biomarker inclusion criterion for melatonin clinical trials.

Breast carcinoma is the most common disease being investigated in melatonin clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Melatonin
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating melatonin and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
melatonin, melatonin [chemical/ingredient], acetamide, n-(2-(5-methoxy-1h-indol-3-yl)ethyl)-, n-[2-(5-methoxyindol-3-yl)ethyl]acetamide, melatonine, melanocyte-inhibiting factor, melatonin (substance), melatonin, n-acetyl-5-methoxytryptamine, 5-methoxy-n-acetyltryptamine, 5-methoxy-n-acetyltryptamine, mih, n-[2-(5-methoxy-1h-indol-3-yl)ethyl]acetamide
NCIT ID [1]:
C2267
SNOMED ID [1]:
F-B7080

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.