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ascorbic acid

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Overview

NCI Definition [1]:
A natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries. Found in citrus and other fruits, and in vegetables, vitamin C cannot be produced or stored by humans and must be obtained in the diet. (NCI04)

Clinical Trials

View Clinical Trials for ascorbic acid

Ascorbic acid has been investigated in 8 clinical trials, of which 6 are open and 2 are closed. Of the trials investigating ascorbic acid, 1 is phase 1 (1 open), 2 are phase 1/phase 2 (2 open), and 5 are phase 2 (3 open).

TET2 Loss, TET2 Mutation, and BRCA1 Loss (germline) are the most frequent biomarker inclusion criteria for ascorbic acid clinical trials.

Myelodysplastic syndromes, acute myeloid leukemia, and ampulla of vater adenocarcinoma are the most common diseases being investigated in ascorbic acid clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Ascorbic Acid
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Ascorbic Acid
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating ascorbic acid and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
acidum ascorbinicum, ascorbic acid, l-ascorbic acid, 50-81-7, cecon, ascorbic acid preparation, cenolate, vit c, asorbicap, cevalin, ascorbic acid, c vitamin, ácido ascórbico, acidum ascorbicum, acid, l-ascorbic, vitamin c preparation (product), l-(+)-ascorbic acid, vitamin c preparation, vitamin c, vitamin c product, cetane, l ascorbic acid, vitamin-c, 2-(1,2-dihydroxyethyl)-4,5-dihydroxy-furan-3-one, 33832, acid, ascorbic, l-ascorbic acid, vitamin c, ascorbic acid product, vitc - ascorbic acid, ascorbic acid (substance), c vitamin, vitamin c drug class, ascorbic acid [chemical/ingredient], c-long, ascorbinsäure, ascorbicap, acide ascorbique, vitamin c, ce-vi-sol, [vt400] vitamin c, l-ascorbic acid, ascorbic acid
NCIT ID [1]:
C285
SNOMED ID [1]:
C-A4600

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.