Drugs /

broccoli sprout/broccoli seed extract supplement

Back to Drugs List

Overview

Trade Name(s):
Avmacol
NCI Definition [1]:
A tablet-based nutritional supplement composed of a mixture of sprout and seed extracts of the cruciferous vegetable broccoli, with potential chemopreventive and antioxidant activities. Broccoli sprout/broccoli seed extract contains a high amount of both the glycosinolate glucoraphanin and the enzyme myrosinase, which catalyzes the production of glucoraphanin to sulforaphane. Upon administration of the broccoli sprout/broccoli seed extract, sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs promote the transcription of antioxidant and detoxifying enzymes, particularly glutathione-S-transferase and NAD(P)H dehydrogenase [quinone] 1 (NAD(P)H:quinone oxidoreductase; NQO1), resulting in the detoxification of highly reactive carcinogens. This accelerates the elimination of carcinogens, may protect against cellular damage, and prevents cancer formation. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes.

Clinical Trials

View Clinical Trials for broccoli sprout/broccoli seed extract supplement

Broccoli sprout/broccoli seed extract supplement has been investigated in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial investigating broccoli sprout/broccoli seed extract supplement, 1 is early phase 1 (0 open).

HPV Negative is the most frequent biomarker inclusion criterion for broccoli sprout/broccoli seed extract supplement clinical trials.

Head and neck squamous cell carcinoma, hypopharyngeal squamous cell carcinoma, and laryngeal squamous cell carcinoma are the most common diseases being investigated in broccoli sprout/broccoli seed extract supplement clinical trials [2].

Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Broccoli Sprout/broccoli Seed Extract Supplement
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating broccoli sprout/broccoli seed extract supplement and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
Avmacol
NCIT ID [1]:
C128293

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.