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carmustine

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Overview

Generic Name(s):
carmustine
Trade Name(s):
Carmustinum, Bicnu, Becenum, Carmubris, Nitrourean, and Nitrumon
NCI Definition [1]:
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)

Clinical Trials

View Clinical Trials for carmustine

Carmustine has been investigated in 16 clinical trials, of which 14 are open and 2 are closed. Of the trials investigating carmustine, 5 are phase 1 (4 open), 3 are phase 1/phase 2 (3 open), 5 are phase 2 (4 open), and 3 are phase 3 (3 open).

MYC Fusion, ALK Alternative Transcription Site, and ALK Amplification are the most frequent biomarker inclusion criteria for carmustine clinical trials.

Diffuse large B-cell lymphoma, non-hodgkin lymphoma, and follicular lymphoma are the most common diseases being investigated in carmustine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Carmustine
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Carmustine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating carmustine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
Becenum, BiCNU, Carmubris, Carmustinum, Nitrourean, Nitrumon, camustine, fivb, becenun, carmustine, 1,3-bis(2-chloroethyl)-1-nitrosourea, carmustina, fda 0345, wr-139021, sk 27702, carmustine (product), 1,3-bis(beta-chloroethyl)-1-nitrosourea, bis(chloroethyl) nitrosourea, bis-chloroethylnitrosourea, gliadel, 1,3-bis(2-chloroethyl)-1-nitrosourea, 969, bis chloroethylnitrosourea, sri 1720, carmustin, bis(chloroethyl) nitrosourea, bcnu (bis chloroethylnitrosourea), bis-chloronitrosourea, 1,3-bis(beta-chloroethyl)-1-nitrosourea, n,n'-bis(2-chloroethyl)-n-nitrosourea, carmustine, bicnu (tn), bischloroethyl nitrosourea, 409962, bis-chloronitrosourea, n,n'-bis(2-chloroethyl)-n-nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea, bcnu, urea, n,n'-bis(2-chloroethyl)-n-nitroso-, carmustine [chemical/ingredient], carmustine (substance), n,n'-bis(2-chloroethyl)-n-nitrosourea, carmustin, bcnu - carmustine, 154-93-8
Drug Categories [2]:
Alkylating agents
NCIT ID [1]:
C349
SNOMED ID [1]:
F-61A8C

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.