Drugs /
chlorambucil
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Overview
Generic Name(s):
chlorambucil
Trade Name(s):
Amboclorin, Linfolizin, Ambochlorin, Chloraminophene, Alti-Chlorambucil, Leukeran, and Linfolysin
NCI Definition [1]:
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
Biomarker-Directed Therapies
Clinical Trials
Chlorambucil has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating chlorambucil, 2 are phase 3 (2 open).
Drug Details
Synonyms [2]:
benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)-, Ambochlorin, Amboclorin, Leukeran, Linfolizin, Alti-chlorambucil, Chloraminophene, Linfolysin, chlorbutine, .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid, wr-139013, 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid, chlorbutinum, cb1348, 4-[bis(2-chloroethyl)amino]benzenebutanoic acid, chlorambucil, n,n-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, ecloril, 305-03-3, chlorambucil (product), γ-[p-di(2-chloroethyl)aminophenyl]butyric acid, chlorbutine, aminochlorambucil, phenylbutyric acid nitrogen mustard, .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid, .gamma.-[p-di(2-chloroethyl)aminophenyl]butyric acid, chlorambucilum, chlorobutin, n,n-di-(2-chloroethyl)-p-aminophenylbutyric acid, gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid, p-n, n-di-(.beta.-chloroethyl)aminophenyl butyric acid, chloroambucil, chlorobutine, benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9ci), 3088, butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl), gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid, n,n-di-2-chloroethyl-gamma-p-aminophenylbutyric acid, 4-(bis(2-chloroethyl)amino)benzenebutanoic acid, butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-, lympholysin, p-(n, n-di-2-chloroethyl)aminophenyl butyric acid, para-n,n-di(b-chloroethyl)aminophenylbutyric acid, chlorambucil [chemical/ingredient], chlorobutin, leukersan, p-n, n-di-(beta-chloroethyl)aminophenyl butyric acid, phenylbutyric acid nitrogen mustard, chlorbutin, chl, n,n-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, clb, cb-1348, benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9ci), p-(n, n-di-2-chloroethyl)aminophenyl butyric acid, chlorambucil (substance), chlorobutine, n,n-di-2-chloroethyl-γ-p-aminophenylbutyric acid, n,n-di-2-chloroethyl-gamma-p-aminophenylbutyric acid, gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid, benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-, 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid, aminochlorambucil, leukoran, 4-[bis(2-chloroethyl)amino]benzenebutanoic acid, chlorambucil, cb 1348, chlorambucilum, 4-(p-bis(β-chloroethyl)aminophenyl)butyric acid, chloraminophen, elcoril, 3074, chloroambucil, phenylbutyric acid nitrogen mustard, butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-, chloraminophen
Drug Categories [2]:
Alkylating agents
NCIT ID [1]:
C362
SNOMED ID [1]:
C-78050
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
