Drugs /

chloroquine

Back to Drugs List

Overview

Generic Name(s):
chloroquine
NCI Definition [1]:
A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

Clinical Trials

View Clinical Trials for chloroquine

Chloroquine has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating chloroquine, 1 is phase 2 (1 open) and 1 is phase 3 (1 open).

Deficient DNA Mismatch Repair (dMMR), H3F3A K28M, and IDH2 R140G are the most frequent biomarker inclusion criteria for chloroquine clinical trials.

Glioblastoma, anaplastic astrocytoma, and diffuse glioma are the most common diseases being investigated in chloroquine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Chloroquine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating chloroquine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
chloroquinium, n(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, chlorochin, chlorochine, 54-05-7, khingamin, chloroquine [chemical/ingredient], chloroquine (product), chloroquine, chloroquinum, 1,4-pentanediamine, n4-(7-chloro-4-quinolinyl)-n1,n1-diethyl-, chloroquina, cloroquina, chloroquine, chloraquine, chloroquine (substance), chingamin
NCIT ID [1]:
C61671
SNOMED ID [1]:
C-56510

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.