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cmp-001

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Overview

NCI Definition [1]:
An agent composed of an unmethylated CpG motif-rich G10 oligonucleotide, which is an agonist of toll-like receptor 9 (TLR9), encapsulated in noninfectious virus-like particles (VLPs), with potential immunostimulating and antineoplastic activities. Upon administration of CMP-001, the VLPs are specifically taken up by and release the oligonucleotide into antigen-presenting cells (APCs), including dendritic cells (DCs). In turn, the oligonucleotide binds to and activates intracellular TLR9. This stimulates immune signaling pathways, induces the innate immune system and may promote the immune system to attack tumor cells. VLPs stimulate the immune system. TLR9, a member of the TLR family, plays a key role in both pathogen recognition and the activation of innate immunity.

Clinical Trials

View Clinical Trials for cmp-001

Cmp-001 has been investigated in 13 clinical trials, of which 12 are open and 1 is closed. Of the trials investigating cmp-001, 3 are phase 1 (2 open), 2 are phase 1/phase 2 (2 open), 7 are phase 2 (7 open), and 1 is phase 2/phase 3 (1 open).

ER Negative, ER No Expression, and HER2 Deficient Expression are the most frequent biomarker inclusion criteria for cmp-001 clinical trials.

Melanoma, cutaneous melanoma, and head and neck squamous cell carcinoma are the most common diseases being investigated in cmp-001 clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Cmp-001
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Cmp-001
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating cmp-001 and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
vlp-encapsulated tlr9 agonist cmp-001, cyt-003, arb-1598, cyt 003
Drug Target(s) [2]:
TLR9
NCIT ID [1]:
C126422

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.