Drugs /
corticosteroid-containing eye drop
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Overview
NCI Definition [1]:
A sterile ophthalmic solution containing a corticosteroid, with anti-inflammatory activity. Upon application of the corticosteroid-containing eye drop into the eye, the corticosteroid binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism.
Clinical Trials
Corticosteroid-containing eye drop has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating corticosteroid-containing eye drop, 1 is phase 3 (1 open).
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
