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cyclophosphamide

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Overview

Generic Name(s):
cyclophosphamide
Trade Name(s):
Cyclostin, Cytoxan, Cyclo-Cell, Carloxan, Genoxal, Endoxana, Cycloblastin, Fosfaseron, Cicloxal, Cycloblastine, Procytox, Cyclostine, Sendoxan, Neosar, Enduxan, Cytophosphan, Ledoxina, Endoxan, and Clafen
NCI Definition [1]:
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

Clinical Trials

View Clinical Trials for cyclophosphamide

Cyclophosphamide has been investigated in 612 clinical trials, of which 503 are open and 109 are closed. Of the trials investigating cyclophosphamide, 14 are early phase 1 (12 open), 209 are phase 1 (173 open), 97 are phase 1/phase 2 (78 open), 204 are phase 2 (162 open), 10 are phase 2/phase 3 (7 open), 64 are phase 3 (60 open), 3 are phase 4 (3 open), and 11 are no phase specified (8 open).

HER2 Deficient Expression, HER2 Negative, and del(5)(q10) are the most frequent biomarker inclusion criteria for cyclophosphamide clinical trials.

Breast carcinoma, acute myeloid leukemia, and diffuse large B-cell lymphoma are the most common diseases being investigated in cyclophosphamide clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Cyclophosphamide
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Cyclophosphamide
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating cyclophosphamide and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
cpm, Clafen, Cytoxan, Neosar, Carloxan, Cicloxal, wr-138719, monohydrate, cyclophosphamide, n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate, cyclophosphamide [chemical/ingredient], n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorin-2-amine 2-oxide, ctx, bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate, (+,-)-2-(bis(2-chloroethyl)amino)tetrahydro-2h-1,3,2-oxazaphosphorine 2-oxide monohydrate, cyclophosphan, cyclophospham, (+-)-cyclophosphamide, Sendoxan, Procytox, Ledoxina, Genoxal, Fosfaseron, Enduxan, Endoxana, Endoxan, Cytophosphan, Cyclostine, Cyclostin, CYCLO-cell, Cycloblastine, Cycloblastin, 2-[bis(2-chloroethylamino)]-tetrahydro-2h-1,3,2-oxazaphosphorine-2-oxide, 2h-1,3,2-oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate, (-)-cyclophosphamide, cyclophosphamide, asta b 518, cyclophosphamidum, 6055-19-2 (monohydrate), cyclophosphane, cpm - cyclophosphamide, cyt - cyclophosphamide, b-518, bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate, n,n-bis(2-chloroethyl)-n'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate, ciclofosfamida, wr- 138719, ciclofosfamide, genuxal, ctx - cyclophosphamide, cytophosphane, 2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate, cyclophosphamid, (rs)-cyclophosphamide, cytoxan®, cyclophosphamide, n,n-bis(b-chloroethyl)-n',o-trimethylenephosphoric acid ester diamide monohydrate, bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate, 7089, 4173, cyclophosphamide monohydrate, b 518, n,n-bis(2-chloroethyl)-n',o-propylenephosphoric acid ester diamide monohydrate, mitoxan, 2-[bis(2-chloroethyl)amino]tetrahydro-2h-1,3,2-oxazaphosphorine 2-oxide monohydrate, (-)-cyclophosphamide, cyclophosphamid monohydrate, cyt, 2h-1,3,2-oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, syklofosfamid, claphene, cp monohydrate, bis(2-chloroethyl)phosphoramide cyclic propanolamide ester, revimmune, 26271, n,n-bis(beta-chloroethyl)-n',o-trimethylenephosphoric acid ester diamide monohydrate, 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate, cyclophosphanum, cyclophosphamide (substance), cyclophosphamide (product), b518, zytoxan, n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester diamide monohydrate
Drug Categories [2]:
Alkylating agents
NCIT ID [1]:
C405
SNOMED ID [1]:
C-78070

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.