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cyclosporine

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Overview

NCI Definition [1]:
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)

Clinical Trials

View Clinical Trials for cyclosporine

Cyclosporine has been investigated in 25 clinical trials, of which 11 are open and 14 are closed. Of the trials investigating cyclosporine, 1 is early phase 1 (0 open), 5 are phase 1 (2 open), 1 is phase 1/phase 2 (1 open), 14 are phase 2 (6 open), 1 is phase 2/phase 3 (1 open), 1 is phase 3 (0 open), and 2 are no phase specified (1 open).

KMT2A Fusion, del(5)(q10), and BCR-ABL1 Fusion are the most frequent biomarker inclusion criteria for cyclosporine clinical trials.

Acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndromes are the most common diseases being investigated in cyclosporine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Cyclosporine
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Cyclosporine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating cyclosporine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
cysp, cyclosporin, ol 27 400, ciclosporin product, cyclosporine, cyclosporine a, cya - cyclosporin, cyclosporin product, cyclosporine (substance), cyclosporin a, sangcya, sandimmune, ciclosporin, cyclosporine, neoral, ol 27400, neoral, 290193, ol 27-400, sandimmune, cyclosporine [chemical/ingredient], csa - cyclosporin a, cya, csa, cya - cyclosporin a, cyclosporine, cyclosporin, cyclosporine (product), sandimmune, cya, 59865-13-3, sandimmun, gengraf, ciclosporin, 27-400, cyclosporin a, sangcya
NCIT ID [1]:
C406
SNOMED ID [1]:
C-79020

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.