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cytokine-induced killer cells

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Overview

NCI Definition [1]:
A preparation of autologous lymphocytes with potential immunopotentiating and antineoplastic activities. Cytokine-induced killer (CIK) cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T lymphocytes, generated ex-vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal antibody, interleukin (IL)-2, IL-1, and interferon gamma (IFN-gamma) and then expanded. When reintroduced back to patients after autologous stem cell transplantation, CIK cells may recognize and kill tumor cells associated with minimal residual disease (MRD). CIK cells may have enhanced cytotoxic activity compared to lymphokine-activated killer (LAK) cells.

Clinical Trials

View Clinical Trials for cytokine-induced killer cells

Cytokine-induced killer cells has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating cytokine-induced killer cells, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).

ASXL1 Loss, ASXL1 Mutation, and BCR-ABL1 Fusion are the most frequent biomarker inclusion criteria for cytokine-induced killer cells clinical trials.

Acute myeloid leukemia, hepatocellular carcinoma, and myelodysplastic syndromes are the most common diseases being investigated in cytokine-induced killer cells clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Cytokine-Induced Killer Cells
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating cytokine-induced killer cells and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
cik cells, cytokine induced killer cells, cik cells, killer cell, cytokine-induced, cytokine-induced killer cells, cik, cik cell, killer cells, cytokine-induced, cytokine-induced killer cell, autologous cytokine-induced killer cells
NCIT ID [1]:
C71757

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.