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danazol

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Overview

NCI Definition [1]:
A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)

Clinical Trials

View Clinical Trials for danazol

Danazol has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating danazol, 1 is phase 3 (1 open).

KMT2A Fusion, KMT2A-AFF1 Fusion, and KMT2A-ELL Fusion are the most frequent biomarker inclusion criteria for danazol clinical trials.

Myelofibrosis transformation in essential thrombocythemia, polycythemia vera, post-polycythemic myelofibrosis phase, and primary myelofibrosis are the most common diseases being investigated in danazol clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Danazol
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating danazol and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
danazol preparation, danazol (substance), cyclomen, danazol product, danatrol, 17230-88-5, danazolum, danazol preparation (product), 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1h-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol, (17alpha)-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, 270916, dan, 17alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole, win-17757, danazol, (17alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol, sanofi brand of danazol, danazol [chemical/ingredient], winobanin, bonzol, 17alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole, (17alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol, danoval, chronogyn, ladogal, sanofi synthelabo brand of danazol, win 17757, sanofi winthrop brand of danazol, danazol, pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-, danocrine, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1h-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol, danol
NCIT ID [1]:
C414
SNOMED ID [1]:
C-A0510

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.