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defined green tea catechin extract

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Overview

NCI Definition [1]:
A proprietary formulation composed of a defined, decaffeinated green tea extract, containing polyphenolic flavonol catechins, isolated from the plant Camellia sinensis with antiviral, antioxidant, and potential chemopreventive activities. The primary catechins found in green tea are epicatechin (EC), epigallocatechin (EGC), epicatechin-3 gallate (ECG), and epigallocatechin-3-gallate (EGCG), the most potent. As potential chemopreventive agents, catechins scavenge free radicals; inhibit enzymes involved in cell replication and DNA synthesis; interfere with cell-to-cell contact adhesion; and inhibit various intracellular communication pathways required for cell division. In addition, it has been postulated that EGCG may trap growth factors such platelet-derived growth factor (PDGF) on cell membranes, immobilizing growth factors on cell membranes and preventing ligand-receptor crosslinking and growth factor receptor activation.

Clinical Trials

View Clinical Trials for defined green tea catechin extract

Defined green tea catechin extract has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating defined green tea catechin extract, 1 is phase 2 (1 open).

Prostate adenocarcinoma is the most common disease being investigated in defined green tea catechin extract clinical trials [2].

Drug Details

Synonyms [2]:
polyphenon e, polyphenon e tm, polyphenon e
NCIT ID [1]:
C38689

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.