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diphenhydramine

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Overview

NCI Definition [1]:
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

Clinical Trials

View Clinical Trials for diphenhydramine

Diphenhydramine has been investigated in 7 clinical trials, of which 6 are open and 1 is closed. Of the trials investigating diphenhydramine, 1 is early phase 1 (1 open), 4 are phase 1 (3 open), and 2 are phase 2 (2 open).

CDKN2A Overexpression, HLA-A*02 Positive, and HPV Positive are the most frequent biomarker inclusion criteria for diphenhydramine clinical trials.

Multiple myeloma, acute lymphoblastic leukemia, and acute myeloid leukemia are the most common diseases being investigated in diphenhydramine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Diphenhydramine
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Diphenhydramine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating diphenhydramine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
diphenylhydramine, diphenhydramine (substance), 2-diphenylmethoxy-n,n-demthylethanamine, diphenhydramine, beta-dimethylaminoethanol diphenylmethyl ether, n-(2-(diphenylmethoxy)ethyl)-n,n-dimethylamine, β-dimethylaminoethyl benzhydryl ether, o-benzhydryldimethylaminoethanol, beta-dimethylaminoethyl benzhydryl ether, difenhidramina, alpha-(2-dimethylaminoethoxy)diphenylmethane, o-benzhydryldimethylaminoethanol, 2-(diphenylmethoxy)-n,n-dimethylethylamine, diphenhydramine, 2-diphenylmethoxy-n,n-dimethylethylamine, benhydramin, diphenhydraminum, diphenhydramine (product), benzhydramine, far 90x2, diphenhydramine product, diphenylhydramine, probedryl, rigidyl, pm 255, 2-(benzhydryloxy)-n,n-dimethylethylamine, diphenhydramine [chemical/ingredient], s51, syntedril, diphenylhydramin, diphenhydramine, ethanamine, 2-(diphenylmethoxy)-n,n-dimethyl-
NCIT ID [1]:
C61728
SNOMED ID [1]:
F-618A6

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.