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floxuridine

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Overview

Generic Name(s):
floxuridine
Trade Name(s):
Fudr
NCI Definition [1]:
A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)

Clinical Trials

View Clinical Trials for floxuridine

Floxuridine has been investigated in 4 clinical trials, of which 4 are open and 0 are closed. Of the trials investigating floxuridine, 3 are phase 2 (3 open) and 1 is phase 3 (1 open).

Deficient DNA Mismatch Repair (dMMR), MLH1 Deficient Expression, and MSH2 Deficient Expression are the most frequent biomarker inclusion criteria for floxuridine clinical trials.

Colorectal adenocarcinoma and cholangiocarcinoma are the most common diseases being investigated in floxuridine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Floxuridine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating floxuridine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
FUDR, beta-5-fluoro-2'-deoxyuridine, fluorodeoxyuridine, fdurd, floxuridine, floxuridinum, 2-deoxy-5-fluorouridine, 5-fluoro-2'-deoxy-beta-uridine, 5-fluorodeoxyuridine, 2'-deoxy-5-fluorouridine, 1-(2-deoxy-beta-d-ribofuranosyl)-5-fluorouracil, fluoruridine deoxyribose, 5-fluoro-2-desoxyuridine, fluoruridine deoxyribose, fluorouridine deoxyribose, 27640, 5-fudr, floxuridine, 1beta-d-2'-deoxyribofuranosyl-5-flurouracil, fudr, floxuridin, 947, 5-fluorouridine deoxyribose, 2-deoxy-5-fluorouridine, floxiridina, 5 fluorodeoxyuridine, uridine, 2'-deoxy-5-fluoro-, fluoruridine deoxyribose, 5-fudr, 50-91-9, wr-138720, floxuridine (substance), floxuridin, 5-fluorouracil deoxyriboside, fluorodeoxyuridine, 5fudr, 5-fluorouracil deoxyriboside, fudr brand of floxuridine, 2'-deoxy-5-fluorouridine, 1-beta-d-2'-deoxyribofuranosyl-5-flurouracil, floxuridine (product), 5 fluorodeoxyuridine, 1-(2-deoxy-beta-d-ribofuranosyl)-5-fluorouracil, 5-fluorouracil deoxyriboside, 5-fluoro-2'-deoxyuridine, fluorouridine deoxyribose, 5-fluoro-2'-deoxyuridine, 5-fluoro-2'-deoxy-beta-uridine, 5-fluorodeoxyuridine, deoxyfluorouridine, fudf, fdur, fdu, 5-fluorouridine deoxyribose, floxuridine [chemical/ingredient], 5-fluorouracil 2'-deoxyriboside, 5fdu
Drug Categories [2]:
Antimetabolites
NCIT ID [1]:
C504
SNOMED ID [1]:
C-780E0

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.