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gallium ga 68-labeled psma-11

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Overview

NCI Definition [1]:
A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting ligand, Glu-urea-Lys(Ahx) (Glu-NH-CO-NH-Lys(Ahx)), conjugated, via the acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC), to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-labeled PSMA-11, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during PET imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.

Clinical Trials

View Clinical Trials for gallium ga 68-labeled psma-11

Gallium ga 68-labeled psma-11 has been investigated in 3 clinical trials, of which 2 are open and 1 is closed. Of the trials investigating gallium ga 68-labeled psma-11, 1 is phase 1 (1 open) and 2 are phase 1/phase 2 (1 open).

Prostate adenocarcinoma is the most common disease being investigated in gallium ga 68-labeled psma-11 clinical trials [2].

Drug Details

Synonyms [2]:
68ga-psma-hbed-cc, 68ga-psma-11, 68ga-psma, 68ga-labeled glu-nh-co-nh-lys(ahx)-hbed-cc, 68ga-hbed-cc-psma, 68ga-dkfz-psma-11, (68ga)glu-urea-lys(ahx)-hbed-cc, (68)gallium-psma ligand glu-urea-lys(ahx)-hbed-cc, (68)ga-psma ligand glu-urea-lys(ahx)-hbed-cc, (68)ga-labeled glu-urea-lys(ahx)-hbed-cc, (68)ga labeled glu-nh-co-nh-lys(ahx)-hbed-cc, psma-hbed-cc ga-68, gapsma, gallium-68 psma ligand glu-urea-lys(ahx)-hbed-cc, gallium-68 psma, gallium ga 68-labeled psma-11, gallium ga 68 psma-11, ga-68 labeled psma-11, ga-68 labeled dkfz-psma-11, ga psma, [68ga]gapsma-11, [68ga] prostate-specific membrane antigen 11
NCIT ID [1]:
C118961

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.