Drugs /
gsk6097608
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Overview
NCI Definition [1]:
A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor CD96 (Tactile; T cell activation increased late expression), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD96 monoclonal antibody GSK6097608 targets, binds to and inhibits CD96 expressed primarily on T-cells and natural killer (NK) cells, thereby preventing its downstream signaling pathways. This may abrogate CD96-mediated inhibition of T-cell and NK cell effector function and may restore immune function and anti-tumor immune responses through the activation of T-cells and NKs. This may kill and inhibit growth of tumor cells. CD96, a type I transmembrane glycoprotein of the immunoglobulin superfamily and immunological checkpoint for CD8+ T-cells and NK cells, negatively regulates T-cell and NK cell activation and is overexpressed in a variety of cancer settings.
Clinical Trials
Gsk6097608 has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating gsk6097608, 1 is phase 1 (1 open).
Malignant solid tumor is the most common disease being investigated in gsk6097608 clinical trials [2].
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
