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ibuprofen

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Overview

NCI Definition [1]:
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

Clinical Trials

View Clinical Trials for ibuprofen

Ibuprofen has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating ibuprofen, 1 is phase 1 (1 open).

IL3RA Expression is the most frequent biomarker inclusion criterion for ibuprofen clinical trials.

Acute lymphoblastic leukemia and hematopoietic and lymphoid malignancy are the most common diseases being investigated in ibuprofen clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Ibuprofen
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating ibuprofen and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
256857, alpha-methyl-4-(2-methylpropyl)benzeneacetic acid, benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, ibuprofen, (4-isobutylphenyl)-alpha-methylacetic acid, p-isobutylhydratropic acid, (+-)-ibuprofen, 2-(4-isobutylphenyl)propanoic acid, benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, p-isobutylhydratropic acid, ibuprofen, alpha-(p-isobutylphenyl)propionic acid, ibuprofen (substance), ibuprofen [chemical/ingredient], ibuprophen, motrin, propionic acid-ibuprofen, (+-)-p-isobutylhydratropic acid, (+-)-2-(p-isobutylphenyl)propionic acid, p-isobutylhydratropic acid, ibuprofen (product), (rs)-ibuprofen, benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, p-isobutylhydratropic acid, 15687-27-1, (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid, advil, para-isobutylhydratropic acid, (.+ -.)-p-isobutylhydratropic acid, 4-isobutylhydratropic acid, alpha-(4-isobutylphenyl)propionic acid
NCIT ID [1]:
C561
SNOMED ID [1]:
F-61A59

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.