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isotretinoin

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Overview

Generic Name(s):
isotretinoin
Trade Name(s):
Accutane
NCI Definition [1]:
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

Clinical Trials

View Clinical Trials for isotretinoin

Isotretinoin has been investigated in 9 clinical trials, of which 9 are open and 0 are closed. Of the trials investigating isotretinoin, 1 is phase 1 (1 open), 5 are phase 2 (5 open), and 3 are phase 3 (3 open).

MYCN Amplification is the most frequent biomarker inclusion criterion for isotretinoin clinical trials.

Neuroblastoma, ganglioneuroblastoma, and ganglioneuroblastoma, nodular are the most common diseases being investigated in isotretinoin clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Isotretinoin
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating isotretinoin and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
Accutane, neovitamin a, oratane, cistane, 13 cis retinoate, cis-ra, 13-cis-vitamin a acid, 13-ra, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid, 13-cis-vitamin a acid, isotretinoin, cis-retinoic acid, 13-cis-retinoic acid, neovitamin a acid, roacutan, neovitamin a, isotretinoinum, 13-cis-vitamin a acid, isotrex, roaccutane, 28104, cis-retinoic acid, ro 4 3780, 13-cis retinoic acid, isotretinoin (product), (7e,9e,11e,13z)-retinoic acid, ro-4-3780, topical form isotretinoin, isotretinoine, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid, isotretinoin, 13-cis-retinoic acid, roaccutan, neovitamin a acid, isotretinoinum, sotret, 4759-48-2, claravis, neovitamin a (substance), 13-cis-retinoic acid, amnesteem, retinoicacid-13-cis, ro 43780, 13-cra, 13 cis retinoic acid, isotrexin, 13 cis retinoic acid, ro 4-3780, retinoic acid a cis 013, isotretinoin [chemical/ingredient], 13-cis-retinoate, isotretinoin (substance), accure, topical form isotretinoin (product), 329481, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic acid, isotretinoina, 13-cis retinoic acid, isotretinoino, 13-cra, retinoic acid, 13-cis-, isotretinoin
Drug Categories [2]:
Differentiation inducers
NCIT ID [1]:
C603
SNOMED ID [1]:
C-90054

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.