Overview

Generic Name(s):
lenalidomide
Trade Name(s):
Revlimid
NCI Definition [1]:
A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells.

Biomarker-Directed Therapies

Lenalidomide has been investigated in 159 clinical trials, of which 142 are open and 17 are closed. Of the trials investigating lenalidomide, 1 is early phase 1 (1 open), 43 are phase 1 (35 open), 26 are phase 1/phase 2 (22 open), 62 are phase 2 (58 open), 24 are phase 3 (23 open), 1 is phase 4 (1 open), and 2 are no phase specified (2 open).

del(17)(p10), MS4A1 Expression, and IGH-FGFR3 Fusion are the most frequent biomarker inclusion criteria for lenalidomide clinical trials.

Multiple myeloma, follicular lymphoma, and diffuse large B-cell lymphoma are the most common diseases being investigated in lenalidomide clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Lenalidomide
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Lenalidomide
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating lenalidomide and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
cc-5013, cdc 501, Revlimid, lenalidomide, lenalidomide [chemical/ingredient], cc 5013, imid-1, 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, lenalidomide (product), imid3 cpd, lenalidomide, imid-1, celgene brand of lenalidomide, cc5013, lenalidomide (substance), 3-(4-amino-1-oxo-1,3-dihydro-2h-isoindol-2-yl)piperidine-2,6-dione, 2,6-piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2h- isoindol-2-yl)-, imid3, revimid, 3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Drug Target(s) [2]:
CRBN
NCIT ID [1]:
C2668
SNOMED ID [1]:
C-781E9

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.