Overview

NCI Definition [1]:
The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.

Levonorgestrel has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating levonorgestrel, 1 is phase 1 (1 open).

Diffuse large B-cell lymphoma, follicular lymphoma, and lymphoplasmacytic lymphoma are the most common diseases being investigated in levonorgestrel clinical trials [2].

Drug Details

Synonyms [2]:
17alpha-ethynyl-18-homo-19-nortestosterone, wyeth brand of levonorgestrel, d norgestrel, jadelle, 797-63-7 (levo isomer), norgestrel l, mirena, 18-methylnorethisterone, d(-)-norgestrel, levonorgestrel, 17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one, 17alpha-ethynyl-17-hydroxy-18-methylestr-4-en-3-one, plan b, norplant 2, levonorgestrel, levonelle, levonorgestrel wyeth brand, norplant2, aventis pharma brand of levonorgestrel, 17-ethynyl-18-methyl-19-nortestosterone, levonorgestrel alcala brand, 17-alpha-ethynyl-13-ethyl-19-nortestosterone, (17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, levonorgestrel (substance), l-norgestrel, paladin brand of levonorgestrel, norplant-2, d-norgestrel, (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one, levonova, alcala brand of levonorgestrel, 18-methyl-17-alpha-ethynyl-19-nortestosterone, levonorgestrel preparation, d-(-)-norgestrel, levonorgestrel product, 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)-, (-)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one, schering brand 2 of levonorgestrel, 13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one, 13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one, levonorgestrelum, cerazet, 13-beta-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one, microval, 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one, 797-63-7, women's capital brand of levonorgestrel, l norgestrel, norplant, 17alpha-ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol, levonorgestrel paladin brand, levonorgestrel preparation (product), lévonorgestrel, l-norgestrel, microluton, plan b, levonorgestrel [chemical/ingredient]
NCIT ID [1]:
C47585
SNOMED ID [1]:
C-A1201

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.