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liposomal cytarabine

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Overview

NCI Definition [1]:
A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)

Clinical Trials

View Clinical Trials for liposomal cytarabine

Liposomal cytarabine has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating liposomal cytarabine, 2 are phase 2 (2 open).

MS4A1 Expression is the most frequent biomarker inclusion criterion for liposomal cytarabine clinical trials.

Burkitt lymphoma, diffuse large B-cell lymphoma, and B-cell lymphoblastic lymphoma are the most common diseases being investigated in liposomal cytarabine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Liposomal Cytarabine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating liposomal cytarabine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
depofoam-encapsulated cytarabine, dtc 101, depofoam encapsulated cytarabine, 715320, cytarabine liposome, cytarabine liposome, depo-cyt, liposomal cytarabine, liposomal cytarabine, cytarabine liposome, encapsulated cytarabine, cytarabine liposome, cytarabine liposomal, cytarabine liposomal (product), depocyte, cytarabine liposome (substance), depocyt
NCIT ID [1]:
C2388
SNOMED ID [1]:
C-78081

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.