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lithium carbonate

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Overview

NCI Definition [1]:
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.

Clinical Trials

View Clinical Trials for lithium carbonate

Lithium carbonate has been investigated in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial investigating lithium carbonate, 1 is phase 1 (0 open).

CBFB-MYH11 Fusion, KMT2A Fusion, and RUNX1-RUNX1T1 Fusion are the most frequent biomarker inclusion criteria for lithium carbonate clinical trials.

Acute myeloid leukemia is the most common disease being investigated in lithium carbonate clinical trials [2].

Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Lithium Carbonate
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating lithium carbonate and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
lithonate, lithane, lithium carbonate (product), lithium carbonate (substance), dilithium carbonate, lithium carbonate, lithium carbonate, lithium carbonate preparation, carbonate, lithium, carbonate, dilithium, lithium, lithium carbonate, lithotabs, lithium carbonate [chemical/ingredient], eskalith, escalith, carbonic acid, dilithium salt, lithobid
NCIT ID [1]:
C1318
SNOMED ID [1]:
C-15402

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.