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mannitol

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Overview

NCI Definition [1]:
A naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.

Clinical Trials

View Clinical Trials for mannitol

Mannitol has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating mannitol, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).

EGFR Overexpression is the most frequent biomarker inclusion criterion for mannitol clinical trials.

Glioblastoma, anaplastic astrocytoma, and anaplastic oligoastrocytoma are the most common diseases being investigated in mannitol clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Mannitol
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating mannitol and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
mannitol [chemical/ingredient], 407017, e421 - mannitol, mannitol (substance), mannitol, osmitrol, 69-65-8, fraxinine, (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol, mannitol, mannitolum, d-mannitol, manitol, mannitol product, d-mannitol, resectisol, mannitol (product), mannitol, d-, d-(-)-mannitol, (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexol, mannit, manna sugar, cordycepic acid, mannite
NCIT ID [1]:
C625
SNOMED ID [1]:
F-61A38

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.