Drugs /
mechlorethamine
Back to Drugs List
Overview
Trade Name(s):
Valchlor
NCI Definition [1]:
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
Clinical Trials
Mechlorethamine has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating mechlorethamine, 1 is early phase 1 (1 open).
Drug Details
Synonyms [2]:
hn2, mechlorethamine (substance), nitrogen mustard, mechlorethamine [chemical/ingredient], nh-2, hn 2, bis(2-chloroethyl)methylamine, chlorethazine, β,β'-dichlorodiethyl-n-methylamine, mechlorethamine, mustard, bis(beta-chloroethyl)methylamine, chlormethine, chloromethine, bis(2-chloroethyl)methylamine, chlorethazine, methylbis(2-chloroethyl)amine, ethanamine, 2-chloro-n-(2-chloroethyl)-n-methyl-, methylbis(beta-chloroethyl)amine, methylchlorethamine, chlormethine, beta,beta'-dichlorodiethyl-n-methylamine, ethanamine,2-chloro-n-(2-chloroethyl)-n-methyl, 2,2'-dichloro-n-methyldiethylamine, nh2, n-methyl-bis(beta-chloroethyl)amine, nm, mustine, methylbis(beta-chloroethyl)amine, methylchlorethamine, nitrogen mustard, mechlorethamine (product), hn>2<, mechlorethamine, chloramin, n-methyl-bis(2-chloroethyl)amine, hn2, valchlor
NCIT ID [1]:
C62056
SNOMED ID [1]:
C-78130
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
