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megestrol acetate

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Overview

Generic Name(s):
megestrol acetate
Trade Name(s):
Pallace, Niagestin, Megestil, Ovaban, Maygace, and Megace
NCI Definition [1]:
The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells.

Clinical Trials

View Clinical Trials for megestrol acetate

Megestrol acetate has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating megestrol acetate, 2 are phase 2 (2 open).

ER Expression, ER Positive, and HER2 Deficient Expression are the most frequent biomarker inclusion criteria for megestrol acetate clinical trials.

Breast adenocarcinoma and endometrial intraepithelial neoplasia are the most common diseases being investigated in megestrol acetate clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Megestrol Acetate
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating megestrol acetate and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
17α-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, megestrol acetate preparation, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 6-methyl-17α-hydroxy-delta(sup 6)-progesterone acetate, megestrol acetate, 17α-acetoxy-6-dehydro-6-methylprogesterone, bristol myers brand of megestrol acetate, megestrol acetate (substance), 6-methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione acetate, 6-dehydro-6-methyl-17.alpha.-acetoxyprogesterone, 6-methyl-6-dehydro-17.alpha.-acetoxyprogesterone, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate, 6-methyl-17α-acetoxypregna-4,6-diene-3,20-dione, 6-methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione, 17alpha-acetoxy-6-dehydro-6-methylprogesterone, 17-acetoxy-6-methylpregna-4,6-diene-3,20-dione, megestrol acetate, 6-methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone, 6-dehydro-6-methyl-17alpha-acetoxyprogesterone, squibb brand of megestrol acetate, 17alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17.alpha.-acetoxy-6-methylpregna-4,6-diene-3,20-dione, 6-methyl-delta(sup 6)-dehydro-17α-acetoxyprogesterone, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, megostat, bristol-myers brand of megestrol acetate, 6-methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione acetate, 6-methyl-6-dehydro-17alpha-acetoxyprogesterone, megestrol acetate [chemical/ingredient], megestrol acetate preparation (product), 6-methyl-delta(sup 4,6)-pregnadien-17α-ol-3,20-dione acetate, 6-dehydro-6-methyl-17α-acetoxyprogesterone, bdh-1298, sc-10363, 6-methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, megestat, megestrol acetate, Megestil, Maygace, Pallace, Ovaban, Megace, mga, Niagestin, acetate, megestrol, 6-methyl-6-dehydro-17α-acetoxyprogesterone, 6-dehydro-6-methyl-17 alpha-acetoxyprogesterone, (9beta,10alpha)-17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione, 17 alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione, 6-methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate, bdh 1298, bristol myers squibb brand of megestrol acetate, bristol-myers squibb brand of megestrol acetate
Drug Categories [2]:
Progesterone receptor agonists
NCIT ID [1]:
C1156
SNOMED ID [1]:
C-78141

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.