Drugs /
mitotane
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Overview
Generic Name(s):
mitotane
Trade Name(s):
Lysodren and Lisodren
NCI Definition [1]:
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)
Clinical Trials
Mitotane has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating mitotane, 1 is phase 3 (1 open).
Adrenal cortex carcinoma is the most common disease being investigated in mitotane clinical trials [2].
Drug Details
Synonyms [2]:
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene, o,p' - ddd, 2, 2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane, khloditan, ddd, 38721, ddd o p, op'ddd - mitotane, wr-13045, cb 313, ortho,para-ddd, mitotane (substance), mitotano, chlodithane, 2,4'-dichlorodiphenyldichloroethane, mitotane (product), mitotane, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane, 53-19-0, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane, 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, mitotanum, 2, 4'-dichlorodiphenyldichloroethane, o,p-ddd, cb-313, mitotane, ortho para ddd, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, chloditan, o,p'-ddd, o,p'-ddd, 1, 1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-, mitotan, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene, 2,4'-dichlorodiphenyldichloroethane, mitotane [chemical/ingredient], Lisodren, Lysodren, ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-, mytotan, (o,p)-ddd, ortho,para-ddd, ortho,para ddd, piprine-ddd, o-
Drug Categories [2]:
Hormone antagonists
NCIT ID [1]:
C664
SNOMED ID [1]:
C-781A0
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
