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mitoxantrone hydrochloride
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Overview
NCI Definition [1]:
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
Clinical Trials
Mitoxantrone hydrochloride has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating mitoxantrone hydrochloride, 1 is phase 1/phase 2 (1 open).
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].
2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
