Drugs /

poly iclc

Back to Drugs List

Overview

NCI Definition [1]:
A synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. (NCI04)

Clinical Trials

View Clinical Trials for poly iclc

Poly iclc has been investigated in 37 clinical trials, of which 30 are open and 7 are closed. Of the trials investigating poly iclc, 22 are phase 1 (18 open), 10 are phase 1/phase 2 (8 open), and 5 are phase 2 (4 open).

HLA-A*02 Positive, ER Negative, and ER No Expression are the most frequent biomarker inclusion criteria for poly iclc clinical trials.

Melanoma, breast carcinoma, and colorectal carcinoma are the most common diseases being investigated in poly iclc clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Poly Iclc
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Poly Iclc
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating poly iclc and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
poly i:polyc with poly-1-lysine stabilizer, poly i:poly c with poly-l-lysine stabilizer, 39200, polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose, poly iclc, polyi:polyc with poly-l-lysine stabilizer, p.i.c.l.c., 59789-29-6, 301463, stabilized polyriboinosinic/polyribocytidylic acid, polyriboinosinic-polyribocytidylic acid-polylysine carboxymethylcellulose, poly-iclc, 1908, poly i:poly c with poly-1-lysine stabilizer, stabilized polyriboinosinic/polyribocytidylic acid, polyriboinosinic-polyribocytidylic acid-polylysine carboxymethylcellulose, hiltonol, hiltonol
NCIT ID [1]:
C1198

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.