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prednisolone

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Overview

NCI Definition [1]:
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)

Clinical Trials

View Clinical Trials for prednisolone

Prednisolone has been investigated in 14 clinical trials, of which 13 are open and 1 is closed. Of the trials investigating prednisolone, 1 is early phase 1 (1 open), 2 are phase 1 (2 open), 3 are phase 1/phase 2 (3 open), 4 are phase 2 (3 open), 3 are phase 3 (3 open), and 1 is no phase specified (1 open).

MS4A1 Expression, BCR-ABL1 Fusion, and EBV Positive are the most frequent biomarker inclusion criteria for prednisolone clinical trials.

Diffuse large B-cell lymphoma, acute lymphoblastic leukemia, and B-cell acute lymphoblastic leukemia are the most common diseases being investigated in prednisolone clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Prednisolone
Top Biomarker Inclusion Criteria for Closed Clinical Trials Investigating Prednisolone
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating prednisolone and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
cortalone, capsoid, klismacort, panafcortelone, frisolona, .delta.1-hydrocortisone, lenisolone, sterane, cortisolone, delta-phoricol, estilsona, opredsone, prednisolonum, delta(1)-hydrocortisone, adnisolone, 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene, delta(1)-dehydrohydrocortisone, 9900, longiprednil, predni-helvacort, prenilone, hostacortin h, prednisolone preparation (product), prednisolone, diadresonf, prednisolone [chemical/ingredient], deltidrosol, 1,2-dehydrohydrocortisone, prednisolona, delta- cortef, prednisolone, aprednislon, prdl, prednicortelone, hydroretrocortine, fisopred, predeltilone, deltacortril, prednisolone preparation, decortin h, delta-diona, pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, metacortandralone, dacortin h, delta(1)hydrocortisone, (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione, deltasolone, prednisolone (substance), delta-f, dhasolone, metacortandralone preparation, deltahydrocortisone preparation, 50-24-8, 1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione, prednisolone, prelone, linola-h-fett n, delta-dehydrohydrocortisone, meti-derm, di-adreson-f, meti derm, delta1-dehydro-hydrocortisone, delta(1)hydrocortisone, linola-h n, pred-clysma, gupisone, delta(1)-dehydrocortisol, delta-cortef, deltahydrocortisone, delta-dehydrocortisol, precortisyl, decaprednil, meticortelone, 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol, 1,2-dehydrohydrocortisone, lepi-cortinolo, delta-hydrocortisone, kuhlprednon, deltahydrocortisone, predni-coelin, di adreson f, hydeltrasol, (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione, dontisolon d, prednisolone product, delta1-dehydro-hydrocortisone, metacortandralone, 2537, hydeltra
NCIT ID [1]:
C769
SNOMED ID [1]:
C-A0190

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.