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pyrimethamine

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Overview

NCI Definition [1]:
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)

Clinical Trials

View Clinical Trials for pyrimethamine

Pyrimethamine has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating pyrimethamine, 1 is phase 1 (1 open) and 1 is phase 1/phase 2 (1 open).

CD19 Expression, CD5 Expression, and Complex karyotype are the most frequent biomarker inclusion criteria for pyrimethamine clinical trials.

Chronic lymphocytic leukemia/small lymphocytic lymphoma and myelodysplastic syndromes are the most common diseases being investigated in pyrimethamine clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Pyrimethamine
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating pyrimethamine and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
primethamine, 5-(4-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, 5-(4'-chlorophenyl)-2,4-diamino-6-ethylpyrimidine, 58-14-0, pyrimethamine (substance), 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine, daraprim, 2,4-diamino-5-chlorophenyl-6-ethylpyrimidine, 2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-, 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine, cd, pyrimethamine, pirimetamina, pyrimethamine [chemical/ingredient], pyrimethamine product, wellcome brand of pyrimethamine, pyrimethamine (product), pyrimethaminum, 3061, pyrimethamine, glaxo wellcome brand of pyrimethamine, 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, glaxosmithkline brand of pyrimethamine
NCIT ID [1]:
C788
SNOMED ID [1]:
C-56540

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.