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sar408701

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Overview

NCI Definition [1]:
An immunoconjugate consisting of anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) conjugated to a cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-CEACAM5 antibody-drug conjugate SAR408701, the antibody moiety targets CEACAM5 on tumor cells. Upon antibody/antigen binding and internalization, the immunoconjugate releases the cytotoxic agent, which results in tumor cell death. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.

Clinical Trials

View Clinical Trials for sar408701

Sar408701 has been investigated in 5 clinical trials, of which 5 are open and 0 are closed. Of the trials investigating sar408701, 1 is phase 1 (1 open), 1 is phase 1/phase 2 (1 open), 2 are phase 2 (2 open), and 1 is phase 3 (1 open).

CEACAM5 Expression, EGFR A763_Y764insFQEA, and EGFR Codon 719 Missense are the most frequent biomarker inclusion criteria for sar408701 clinical trials.

Malignant solid tumor, non-small cell lung carcinoma, and non-squamous non-small cell lung carcinoma are the most common diseases being investigated in sar408701 clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Sar408701
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating sar408701 and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
adc sar408701, anti-ceacam5 antibody-drug conjugate sar408701, anti-ceacam5 antibody-drug conjugate sar408701
Drug Target(s) [2]:
CEACAM5
NCIT ID [1]:
C117229

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.