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so-c101

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Overview

NCI Definition [1]:
A human fusion protein consisting of the cytokine interleukin (IL)-15 and the high-affinity binding sushi+ domain of IL-15 receptor alpha (IL-15Ra), with potential antineoplastic activities. Upon administration, SO-C101 activates and increases the levels of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. SO-C101 is more potent than unmodified IL-15 and does not require endogenous IL-15Ra for its action.

Clinical Trials

View Clinical Trials for so-c101

So-c101 has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating so-c101, 1 is phase 1 (1 open).

Deficient DNA Mismatch Repair (dMMR), ER Negative, and ER No Expression are the most frequent biomarker inclusion criteria for so-c101 clinical trials.

Anal carcinoma, biliary tract carcinoma, and bladder carcinoma are the most common diseases being investigated in so-c101 clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating So-C101
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating so-c101 and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
interleukin-15/interleukin-15 receptor alpha sushi+ domain fusion protein so-c101, il-15/il-15 receptor alpha sushi+ domain fusion protein so-c101, rli 15, rli-15, soc101, so c101, rli15
NCIT ID [1]:
C170516

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.