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sulindac

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Overview

NCI Definition [1]:
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)

Clinical Trials

View Clinical Trials for sulindac

Sulindac has been investigated in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials investigating sulindac, 1 is phase 2 (1 open) and 1 is phase 3 (1 open).

Colorectal carcinoma and pancreatic intraductal papillary-mucinous neoplasm are the most common diseases being investigated in sulindac clinical trials [2].

Drug Details

Synonyms [2]:
mk231, klinoril, (z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1h-indene-3-acetic acid, apo-sulin, apo sulin, sulindac (product), arthrocine, reumofil, sulreuma, (z)-5-fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1h-indene-3-acetic acid, cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid, citireuma, sulindac [chemical/ingredient], sulindacum, 38194-50-2, sulindac sulfoxide, sulindac, reumyl, mk 231, aflodac, mk-231, sulinol, novo-sundac, imbaral, sulindac, clinoril, sulindaco, clisundac, novo sundac, artribid, cis-5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1h-indene-3-acetic acid, 1h-indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (z)-, sulin, algocetil, cis-5-fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid, sulindac (substance), sudac
NCIT ID [1]:
C850
SNOMED ID [1]:
C-60440

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.