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tq-b3525

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Overview

NCI Definition [1]:
An orally available selective inhibitor of the alpha and delta isoforms of phosphatidylinositol 3-kinase (PI3-kinase subunit alpha/delta; PI3K-alpha/delta; PI3Kalpha/delta), with potential antineoplastic activity. Upon oral administration, PI3K alpha/delta inhibitor TQ-B3525 selectively targets, binds to, and inhibits PI3K alpha and delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K-alpha/delta over-expressing tumor cells. PI3K-alpha/delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K-alpha/delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects

Clinical Trials

View Clinical Trials for tq-b3525

Tq-b3525 has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating tq-b3525, 1 is phase 1/phase 2 (1 open).

ER Expression, ER Positive, and HER2 Deficient Expression are the most frequent biomarker inclusion criteria for tq-b3525 clinical trials.

Breast carcinoma is the most common disease being investigated in tq-b3525 clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Tq-B3525
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating tq-b3525 and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
pi3k alpha/delta inhibitor tq-b3525, tq b3525, tqb3525
NCIT ID [1]:
C179252

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.