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white button mushroom extract

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Overview

NCI Definition [1]:
A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells.

Clinical Trials

View Clinical Trials for white button mushroom extract

White button mushroom extract has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating white button mushroom extract, 1 is phase 2 (1 open).

Prostate adenocarcinoma is the most common disease being investigated in white button mushroom extract clinical trials [2].

Drug Details

Synonyms [2]:
wbm extract, wbm extract, white button mushroom extract
NCIT ID [1]:
C78490

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.