Associated Genetic Biomarkers
AFP is a predictive biomarker for use of ramucirumab in patients.
Hepatocellular carcinoma has the most therapies with AFP as a predictive biomarker.
Of the therapies with AFP as a predictive biomarker, 1 is FDA-approved in at least one clinical setting and 1 has NCCN guidelines in at least one clinical setting.
AFP Expression and AFP Overexpression are the top alterations on AFP targeted by therapies .
Hepatocellular Carcinoma -
Sample must match one or more of the following:
|Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Second Line of Therapy (FDA, NCCN)|
|Note: Ramucirumab has been approved as a single agent for the treatment of hepatocellular carcinoma in patients who have an alpha fetoprotein of ≥400 ng/mL and have been treated with sorafenib.|
AFP status serves as an inclusion eligibility criteria in 8 clinical trials, of which 7 are open and 1 is closed. Of the trials that contain AFP status as an inclusion criterion, 2 are phase 1 (2 open), 2 are phase 1/phase 2 (1 open), 1 is phase 2 (1 open), 2 are phase 3 (2 open), and 1 is no phase specified (1 open).
Trials with AFP status in the inclusion eligibility criteria most commonly target hepatocellular carcinoma, adenocarcinoma of the gastroesophageal junction, and gastric adenocarcinoma .
The most frequent alterations to serve as inclusion eligibility criteria are AFP Expression and AFP Overexpression .
Placebo, anti-pd-l1 antibody, c-tcr055, et140202, and synov1.1 are the most frequent therapies in trials with AFP as an inclusion criteria .
Significance of AFP in Diseases
Hepatocellular Carcinoma +
AFP is an inclusion criterion in 7 clinical trials for hepatocellular carcinoma, of which 6 are open and 1 is closed. Of the trials that contain AFP status and hepatocellular carcinoma as inclusion criteria, 2 are phase 1 (2 open), 2 are phase 1/phase 2 (1 open), 2 are phase 3 (2 open), and 1 is no phase specified (1 open) .
Ramucirumab has evidence of efficacy in patients with AFP mutation in hepatocellular carcinoma .
Adenocarcinoma Of The Gastroesophageal Junction +
AFP is an inclusion criterion in 1 clinical trial for adenocarcinoma of the gastroesophageal junction, of which 1 is open and 0 are closed. Of the trial that contains AFP status and adenocarcinoma of the gastroesophageal junction as inclusion criteria, 1 is phase 2 (1 open) .
Gastric Adenocarcinoma +
AFP is an inclusion criterion in 1 clinical trial for gastric adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains AFP status and gastric adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.